GLP-1 medications work by mimicking the incretin hormone glucagon-like peptide-1, which enhances insulin secretion in response to food, suppresses glucagon release, slows gastric emptying, and reduces appetite
In this work, we investigated the physiological role of GLP-1R in mouse brain glucose metabolism
Study outcomes Our primary outcome was suicidality, which we defined as a composite of suicidal ideation (identified in the CPRD), hospital admission for self-harm (identified in HES APC), or completed suicide (identified in ONS)
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